Bovine Respiratory Disease Bovine Respiratory Disease (BRD) is one of the biggest health challenges facing producers today. Stressors contribute to its development, as is the case with “shipping fever”. BRD can develop at any time – even in low- and moderate-risk stocker/backgrounder cattle on pasture.¹ • Economic losses cost cattle producers $1 billion annually¹ • Nearly 25% of the 38 million calves in the United States are pulled due to BRD¹ • Early identification is essential to decrease losses¹ 1.2 1.0 0.8 0.6 0.4 0.2 0.0 1 2 3 4 5 Number of days treated Aureomycin        Oxytetracycline 1.0 0.8 0.6 0.4 0.2 0.0 Time (h) Aureomycin        Oxytetracycline † † † † † 12 24 36 48 60 72 84 96 108 * 0 h: n=31, all treatments decreased by 5 hd each 24 h. 96 h: n=25 Aureomycin and 31 OTC decreased by 5 hd each 24 h. Plasma samples were obtained prior to dose administration. † Dose administration ‡ n=5 per treatment per day; all values are 24 h post final dose. Bovine Respiratory Disease