Alpharma

Technical Bulletin No. GD 0349

Abstract

Aureomycin (chlortetracycline) premix has shown improved stability compared to oxytetracycline in pelleted feed. This is due to the distinct differences between these two compounds in molecular structure, and physical and chemical properties.

Post-pelleting retention of Aureomycin from the mash was greater compared to oxytetracycline in all 10 studies summarized in this Technical Bulletin. Overall, the post-pelleting stability advantage of Aureomycin was shown to be 8.0% over oxytetracycline.

Introduction

Various antimicrobial feed additives, such as the tetracyclines, can deteriorate when exposed to heat, moisture, pressure and/or other feed ingredients during feed manufacturing and storage. The differences in molecular structure and physical and chemical properties of Aureomycin reduce activity loss during feed manufacturing, including pelleting, and subsequent storage of the feed compared to oxytetracycline.

Post-Pelleting Stability of Aureomycin vs Oxytetracycline

The results of ten studies (the current database), comparing the effects of pelleting on Aureomycin and oxytetracycline, were tabulated, and the pooled averages were statistically analyzed using the paired t-test. In each study, after pelleting, retention of Aureomycin from the mash, as determined by assay, was greater compared to oxytetracycline. Overall, post-pelleting, 8.0% more Aureomycin was shown to be retained from the mash than oxytetracycline (Figure 1 and Table 1).

Improved pelleting stability of Aureomycin demonstrates the advantages of this product over oxytetracycline. It also is one of many reasons why Aureomycin is the widely accepted in-feed tetracycline of choice, providing cost- effective health and performance benefits in livestock and poultry production.

FIGURE 1: Overall pelleting stability of Aureomycin and
oxytetracycline; pooled averages of 10 studies.

FIGURE 1: Overall pelleting stability of Aureomycin and
oxytetracycline; pooled averages of 10 studies.

TABLE 1. Pelleting stability of Aureomycin and oxytetracycline;
description of 10 individual studies.

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Comparative Pelleting Stability of Aureomycin® and Oxytetracycline

Abstract

Introduction

Post-Pelleting Stability of Aureomycin vs Oxytetracycline

Comparative Pelleting Stability of Aureomycin^® and Oxytetracycline